It's Gonna Blow...

Dear Auntie Greg, i have a problem, i can't work out if 2,4-dinitrophenylhyrazine bonds to my prepared sample (a ketone) through the carbonyl group or the double bonded oxgyen to form a 2,4-dinitrophenylhyrazone derivative. please, my life depends on it...

Mad Cap Scientist

Mad Cap, is it ok to call you that? I find in situations like this that it is often best to take a step back from the problem, take off that lab coat and have a Jaffa Cake. The carbonyl group simply forms a covalent bond with the nitrogen on your 2,4-dinitrophenylhyrazine reagent and the oxygen merely bonds with two hydrogens to form water as a by-product. You often find the answer has been staring you in the face all along, elementary really! Pardon the pun. Hope this has helped,
Much love,

Auntie Greg x
Return to Auntie Greg's Agony Column